This is a list of the Irish Recorded Music Association's Irish Singles Chart Top 50 number-ones of 2000.
| Issue Date | Song | Artist |
|---|---|---|
| 1 January | I Have a Dream/Seasons in the Sun | Westlife |
| 8 January | ||
| 15 January | ||
| 22 January | Born to Make You Happy | Britney Spears |
| 29 January | ||
| 5 February | Silence | Delerium |
| 12 February | Go Let It Out | Oasis |
| 19 February | Rise | Gabrielle |
| 26 February | Pure Shores | All Saints |
| 4 March | Maniac 2000 | Mark McCabe |
| 11 March | ||
| 18 March | ||
| 25 March | ||
| 1 April | ||
| 8 April | ||
| 15 April | ||
| 22 April | ||
| 29 April | ||
| 6 May | ||
| 13 May | Bad Touch | Bloodhound Gang |
| 20 May | ||
| 27 May | ||
| 3 June | ||
| 10 June | Gotta Tell You | Samantha Mumba |
| 17 June | ||
| 24 June | ||
| 1 July | ||
| 8 July | ||
| 15 July | Life Is A Rollercoaster | Ronan Keating |
| 22 July | The Real Slim Shady | Eminem |
| 29 July | ||
| 5 August | Rock DJ | Robbie Williams |
| 12 August | ||
| 19 August | ||
| 26 August | ||
| 2 September | Groovejet (If This Ain't Love) | Spiller |
| 9 September | ||
| 16 September | Lady (Hear Me Tonight) | Modjo |
| 23 September | Against All Odds (Take a Look at Me Now) | Mariah Carey featuring Westlife |
| 30 September | ||
| 7 October | ||
| 14 October | Beautiful Day | U2 |
| 21 October | ||
| 28 October | ||
| 4 November | My Love | Westlife |
| 11 November | ||
| 18 November | ||
| 25 November | Can't Fight the Moonlight | LeAnn Rimes |
| 2 December | ||
| 9 December | Stan | Eminem featuring Dido |
| 16 December | ||
| 23 December | ||
| 30 December |
|
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